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Indian J Physiol Pharmacol ; 1994 Oct; 38(4): 316-8
Article in English | IMSEAR | ID: sea-106817

ABSTRACT

The influence of ranitidine on the hypoglycaemic activity of glibenclamide and tolbutamide was studied in rabbits. Ranitidine treatment (15 mg/kg, po, twice daily for one week) enhanced the hypoglycaemic activity of glibenclamide (40 micrograms/kg, po) while it has not altered either the hypoglycaemic activity or pharmacokinetics of tolbutamide (40 mg/kg, po) in rabbits.


Subject(s)
Animals , Drug Interactions , Glyburide/pharmacokinetics , Hypoglycemia/chemically induced , Rabbits , Ranitidine/pharmacology , Tolbutamide/pharmacokinetics
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